1.leptospirosis是一种由致病性钩端螺旋体引起的自然疫源性急性传染病,名为----钩端螺旋体病
2.斡旋的疾病典型sysmptoms
Characteristic sysmptoms of superantigen-mediated diseases include:
fever
mucous prduction
diarrhoea
vomiting
shock leading to death
Chronic infection can cause autoimmune diseases and glomurelonephritis.(有的词太难了,不确定,从google找了一些英文,不知有没有用?抱歉)
3.Pathogenic Leptospira spp. cause leptospirosis. Human infection occurs through direct contact with the urine of infected animals or by contact with a urine-contaminated environment, such as surface water, soil and plants. The causative organisms have been found in a variety of both wild and domestic animals, including rodents, insectivores, dogs, cattle, pigs and horses. Leptospires can gain entry through cuts and abrasions in the skin and through mucous membranes of the eyes, nose and mouth. Human-to-human transmission occurs only rarely.
4.潜伏期2~20日,平均10日
The number of human cases worldwide is not well-documented. It probably ranges from 0.1 to 1 per 100 000 per year in temperate climates to 10 or more per 100 000 per year in the humid tropics. During outbreaks and in high-risk groups, 100 or more per 100 000 may be infected. For several reasons leptospirosis is overlooked and consequently underreported in many areas of the world. In the wake of hurricane Mitch in 1995, an outbreak of leptospirosis with pulmonary haemorrhages was reported in Nicaragua. In 1998, there was an outbreak in the continental United States. 1998 also saw an outbreak in Peru and Ecuador following heavy flooding. A post-cyclone outbreak was reported in Orissa, India in 1999.
5.
aim at control at the level of the infection source (e.g. rodent control, animal vaccination);
interrupt the transmission route (e.g. wearing protective clothing, refrain from contact with infected animals and from swimming in contaminated water, provide clean drinking-water); or
prevent infection or disease in the human host (e.g. vaccination, antibiotic prophylaxis, information to doctors, veterinarians, risk groups and the general population).
6.可注射疫苗
(另附加:1.消灭和管理传染源 开展灭鼠保粮灭鼠防病群众运动。结合“两管(水、粪)、五改(水井、厕所、畜圈、炉灶、环境)”工作,尤应提倡圈猪积肥、尿粪管理,从而达到防止污染水源、稻田、池塘、河流的目的。对带菌者和病畜进行检查治疗。对病人的血、脑脊液等严密消毒处理。
2.切断传播途径 结合工农业生产改造疫源地,防洪排涝。保护水源和食物,防止鼠和病畜尿污染。在流行地区和流行季节避免在疫水中游泳、嬉水、涉水。收割水稻前放干田水,或放农药处理;加强个人防护、皮肤涂布防护药。
3.增强个人免疫力 疫区居民、部队及参加收割、防洪、排涝可能与疫水接触的人员,尽可能提前1个月接种与本地区流行菌型相同的钩体多价菌苗。每年2次,间隔7天。剂量成人第1次1ml,第二次2ml。全程注射后人体产生的免疫力可持续1年左右。以后每年仍需同样注射。有心、肾疾患、结核病及发热患者不予注射。
4.药物预防 对高危易感者如孕妇、儿童青少年、老年人或实验室工作人员意外接触钩体、疑似感染本病但无明显症状时,可注射青霉素每日80~120万U,连续2~3日。此外,还可因地制宜选用土茯苓30g,鱼腥草15~30g,穿心莲、金银花等煮水服,或服中药成方“普济消毒饮”加减。
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