Purpose: To determine the patterns of regional recurrence in patients treated with definitive radiotherapy (RT) for
cervical cancer.
Methods and Materials: The records of 198 patients treated with definitive RT for cervical cancer between 1980
and 2000 who experienced a regional recurrence without a central or distal vaginal recurrence were reviewed. All
patients received a combination of external-beam RT and intracavitary brachytherapy. In the 180 patients with
a documented location of regional recurrence, the relationship between the recurrence and the radiation fields
was determined.
Results: The median time to regional recurrence was 13 months (range, 2–85 months). Of the 180 patients who
had an evaluable regional recurrence, 119 (66%) had a component of marginal failure; 71 patients recurred
above-the-field, 2 patients occurred in the inguinal nodes, and 2 patients recurred above-the-field and in the inguinal
nodes. In addition, 105 patients (58%) had a component of in-field failure; 59 patients recurred in-field
only, 39 patients recurred in-field and above-the-field, 2 patients recurred in-field, above-the-field, and in the inguinal
nodes, and 5 patients recurred in-field and in the inguinal nodes. The median survival after regional recurrence
was 8 months (range, 0–194 months).
Conclusions: Most regional recurrences after definitive RT for cervical cancer include a component of marginal failure,
usually immediately superior to the radiation field. These recurrences suggest a deficiency in target volume. Recurrences
also occur in-field, suggesting a deficiency in dose. Developments in pretreatment staging, field delineation,
dose escalation, and posttreatment surveillancemay help to improve outcomein these patients. 2010 Elsevier Inc.
Cervical cancer, Patterns of recurrence, Radiotherapy, Brachytherapy.
如果你翻译的好，不是像上面敷衍了事，我给你50分，够不？