第1个回答 2011-02-01
难度谈不算，但不失文雅：
Please allow to disagree.请允许表达不同看法。
I am afraid that I cannot agree with you.很遗憾，我不同意你的看法。
I don't see eye to eye with you.（这个比较口语了）。
第2个回答 2011-02-01
I'm not agree with you.
我不同意你的看法。
I'm against your opinion.
我反对你的观点。
第3个回答 2011-02-01
I can't agree with you
You could not be more wrong~!(意思应该也相近吧）
I am against you
I am totally not on your side
第4个回答 2011-02-01
I don't think you are right.
I am afraid I can't agree with you.
As far as I know, your opinion is not reasonable.
第5个回答 2011-02-09
I'm afraid that i'm against you.