But more recently, neural stem cells derived from adult animals-which also differentiate into the three cell types-have caused problems. As Christoph Hofstetter of the Karolinnska Institute in Stockholm, Sweden, and his colleagues reported in Nature Neuroscience in March, neural stem cell treatments led to some recovery in rat’s paralyzed hind legs, but the animals also developed a chronic pain sensitivity in their forelegs, which had been unaffected by the injury. In other experiments, preventing the formation of astrocytes seemed to eliminate the side effect, thus highlighting the importance of proper differentiation, Svendsen says.
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