Few，a few，little，a little的区别为：意思不同、用法不同、侧重点不同。
一、意思不同
1、few：（与复数名词和复数动词连用）不多，很少。
2、a few：几个，很多，一点点。
3、little表示几乎没有，是否定意义。
4、a little表示还有一点，还有几个，是肯定意义。
二、用法不同
1、few：few用作代词时，意思是“很少，几个”，作主语时谓语动词须用复数形式。
2、a few：+可数名词复数，表示肯定。基本意思是“小块，少量”，指整体中的一小部分，也可指独立的一小部分。还可指“与集体、人或活动有关的一系列行动、态度”。
3、a little 和 little，其实用法跟 a few 和 few 类似。区别就在于 a little 和 little 只能修饰“不可数名词”。
三、侧重点不同
1、few：few用于可数名词，否定用法。
2、a few：a few一点点，用于修饰可数名词，肯定用法。
3、a little可以用来修饰形容词的比较级，表示有一点。
few，a few，little，a little造句：
1、There are a few flowers in the room.
2、He feels a little tired after working.
3、He can speak a little English.
4、There is a little water in the bottle.
5、She is a little taller than her sister.
6、Few people can resist the temptation of chocolate.
7、I have a few suggestions on how to improve the project.
8、He had little money left after buying the plane ticket.
9、A little bit of patience can go a long way in resolving conflicts.
10、There were few customers in the store during the pandemic.
11、She had a few gray hairs, but otherwise looked young for her age.
12、Little did he know that his life was about to change forever.
13、A little bit of exercise every day can improve your health.
14、There were few opportunities for women in the workforce in the past.
15、I have a few reservations about the plan, but I am willing to discuss them further.